Even fans outside the West Coast might pay extra attention to Week 2 because both the Rams and 49ers are returning from their Australia trip. San Francisco and Los Angeles both get home games — the Niners host Miami on Sunday and the Rams welcome the Giants on Monday — and oddsmakers opened with big edges: San Francisco is a whopping 12.5-point favorite, the largest spread so far this season, while L.A. is laying 7 points to New York as the Giants head into back-to-back primetime games. Claim the latest Polymarket promo code CBSSPORTS to earn a $50 bonus after making $10 in trades.
Bookmakers set at least a touchdown between teams in six Week 2 matchups, reflecting what they learned from Week 1. SportsLine’s projections, driven by an advanced computer model, have been applied to the new Week 2 lines to produce betting advice and picks for every game.
The model runs each matchup 10,000 times and, according to SportsLine, has generated over $7,000 in profit for $100 bettors on its top-rated NFL selections since it began. It comes into Week 2 of the 2026 campaign riding a 53-39 streak on top picks going back to 2024, and those following its guidance on betting sites have seen strong returns. The model’s full set of Week 2 picks is available at SportsLine.
Top Week 2 predictions from the model include Seattle (-3.5, 41) getting the cover at Arizona in the Sunday 4:25 p.m. ET window. The Seahawks beat their Week 1 opponent in the Kickoff Game and historically perform well when they have extra rest — 6-1 against the spread in those situations since early 2025. Seattle has also dominated Arizona lately, winning nine straight and going 8-1 ATS during that streak. While the Cardinals pulled off a surprise over the Chargers in Week 1, they showed discipline issues (111 penalty yards, the second-most in Week 1), and the model forecasts Seattle covering nearly 60% of the time in what it grades as an A-rated pick. See SportsLine for other recommended selections.
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Another key Week 2 call: the Buccaneers (-8.5, 41.5) are projected to cover at home against the Browns in a matchup where Tampa Bay covers in well over half of the simulations. Cleveland looked shaky in Week 1, surrendering 34 points to Jacksonville, taking five sacks on Deshaun Watson, and only managing a late touchdown against reserves. The Bucs were disappointed in a defeat at Cincinnati, but returning to Tampa should help; Cleveland’s 4-14 ATS mark on the road since 2024 is the worst in the league. The model also favors the Over in this game more than 60% of the time. Check SportsLine for the full slate of picks.
The model has locked in winners and covers for every Week 2 contest and even identifies an underdog it expects to win outright by about a touchdown — a pick that could pay off big. To see every pick for every game, visit SportsLine.
Fan Take: This matters because how teams recover from travel and Week 1 surprises will shape early-season narratives and betting markets — momentum and roster health can swing quickly. If the model’s heavier favorites and identified upset pan out, bettors and fans alike will get a clearer picture of which teams are truly contenders and which still need tuning.
Source: www.cbssports.com
