The Seattle Seahawks head to Glendale to take on the Arizona Cardinals on Sunday in a Week 2 matchup airing on FOX.
The reigning Super Bowl champions opened the 2026 season with a 13-10 win over the New England Patriots, but Seattle will be without Sam Darnold after he exited in the first quarter; Drew Lock is expected to start in his place. Seattle erased a 10-0 deficit with 13 straight points, and its defense picked off Drake Maye three times while limiting New England to just 10 points. Coming off a year in which they allowed the fewest points in the NFL (17.2 per game), Seattle’s defense looks set to be a major factor again.
Arizona produced the biggest surprise of Week 1, defeating the Los Angeles Chargers on the road despite being 9.5-point underdogs. A unit that ranked near the bottom in several defensive categories last season held L.A. to 14 points, 209 passing yards and just 3.9 yards per carry, while registering three sacks and steady pressure. On offense, Jacoby Brissett was efficient, completing 27 of 37 passes for 277 yards and a touchdown. Can the Cardinals pull off back-to-back upsets to start the year?
FanDuel odds (as of Sept. 20)
– Moneyline: Seahawks -200 (bet $10 to win $15); Cardinals +168 (bet $10 to win $26.80)
– Spread: Seahawks -3.5 (-110); Cardinals +3.5 (-110)
– Total: 41.5 (-110 on both Over and Under)
From FOX Sports Research: Drew Lock looked sharp in relief Week 1 (16-of-22 for 187 yards and a touchdown), but New England wasn’t prepared for him; Arizona will have a full week to scheme against him. The Cardinals appeared much improved in Mike LaFleur’s first season, especially on defense, and with offensive weapons like Trey McBride, Jeremiyah Love and Marvin Harrison Jr., Arizona has a real shot to be 2-0 — particularly facing a backup quarterback. The pick: Cardinals +3.5.
How to watch
– Date: Sunday, Sept. 20, 2026
– Time: 4:25 p.m. ET
– TV: FOX
– Streaming: FOX One (three-day free trial available), FOXSports.com, FOX Sports App
– Stadium: State Farm Stadium, Glendale, AZ
Fan Take: This game is an early litmus test for Seattle’s quarterback depth and whether Arizona’s offseason changes have meaningfully flipped their defense. If the Cardinals can win or even cover, it would signal that the NFC West could be more competitive than many expect.
Source: www.foxsports.com
