The Week 4 NFL betting lines are out, and bettors are scouting for edges. The slate opens Thursday Night Football with the Cleveland Browns hosting the Pittsburgh Steelers; Pittsburgh is a 2.5-point favorite on the road per current odds. Other notable spreads include Bills -6.5 over New England, Texans -2.5 vs. Dallas, and Chiefs -4.5 against the Raiders. The biggest total on the board is 51.5 for Jaguars vs. Bengals. New users can also take advantage of the DraftKings welcome offer: $150 in bonus bets after a $5 wager.
Note: DraftKings odds are listed below and may move.
Thursday, Oct. 1
– Pittsburgh Steelers at Cleveland Browns
– Spread: Steelers -2.5
– Moneyline: Steelers (-148), Browns (+125)
– Total: 38.5
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Sunday, Oct. 4
– Indianapolis Colts vs. Washington Commanders
– Spread: Colts -3.5
– Moneyline: Colts (-187), Commanders (+155)
– Total: 47
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– New England Patriots at Buffalo Bills
– Spread: Bills -6.5
– Moneyline: Bills (-324), Patriots (+258)
– Total: 48.5
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– Tennessee Titans at Baltimore Ravens
– Spread: Ravens -11.5
– Moneyline: Ravens (-714), Titans (+509)
– Total: 43.5
– Promotion: Caesars Sportsbook promo code CBSSPORTSBR250
– New York Jets at Chicago Bears
– Spread: Bears -3
– Moneyline: Bears (-156), Jets (+132)
– Total: 43
– Promotion: FanDuel promo — $250 in bonus bets
– Jacksonville Jaguars at Cincinnati Bengals
– Spread: Bengals -2.5
– Moneyline: Bengals (-142), Jaguars (+120)
– Total: 51.5
– Promotion: DraftKings welcome — $150 in bonus bets after a $5 wager
– Dallas Cowboys at Houston Texans
– Spread: Texans -2.5
– Moneyline: Texans (-140), Cowboys (+119)
– Total: 47.5
– Promotion: BetMGM bonus code CBSSPORTS — up to $1,500 in bonus bets
– Arizona Cardinals at New York Giants
– Spread: Cardinals -1
– Moneyline: Cardinals (-112), Giants (-106)
– Total: 44.5
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– Los Angeles Rams at Philadelphia Eagles
– Spread: Rams -3
– Moneyline: Rams (-162), Eagles (+136)
– Total: 44
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– Green Bay Packers at Tampa Bay Buccaneers
– Spread: Packers -4
– Moneyline: Packers (-188), Buccaneers (+157)
– Total: 39.5
– Promotion: FanDuel promo — $250 in bonus bets
– Miami Dolphins at Minnesota Vikings
– Spread: Vikings -10.5
– Moneyline: Vikings (-637), Dolphins (+469)
– Total: 38.5
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– Kansas City Chiefs at Las Vegas Raiders
– Spread: Chiefs -4.5
– Moneyline: Chiefs (-222), Raiders (+184)
– Total: 47.5
– Promotion: BetMGM bonus code CBSSPORTS — up to $1,500 in bonus bets
– Denver Broncos at San Francisco 49ers
– Spread: 49ers -2.5
– Moneyline: 49ers (-149), Broncos (+125)
– Total: 46.5
– Promotion: Fanatics Sportsbook promo — get $350 in FanCash
– Los Angeles Chargers at Seattle Seahawks
– Spread: Seahawks -7
– Moneyline: Seahawks (-334), Chargers (+268)
– Total: 43
– Promotion: DraftKings welcome — $150 in bonus bets after a $5 wager
– Detroit Lions at Carolina Panthers
– Spread: Lions -3.5
– Moneyline: Lions (-193), Panthers (+163)
– Total: 50.5
– Promotion: FanDuel promo — $250 in bonus bets
Monday, Oct. 5
– Atlanta Falcons at New Orleans Saints
– Spread: Saints -2.5
– Moneyline: Saints (-151), Falcons (+127)
– Total: 48.5
– Promotion: BetMGM bonus code CBSSPORTS — up to $1,500 in bonus bets
Fan Take: These lines matter because they shape where casual and sharp money flows, which can move odds and affect in-game betting markets as the week progresses. For fans, the spreads and totals also highlight where oddsmakers see potential mismatches or high-scoring affairs, giving insight into which games might be the most exciting to watch.
Source: www.cbssports.com

