The NFL moves into Week 4, closing out the first month of the regular season. After the Browns upset the Steelers on Thursday and following a Week 3 that matched the league record for most one-score games in a week, this upcoming slate carries plenty of intrigue — but injuries remain a major storyline. Several high-profile players are already sidelined for Week 4, including Vikings receiver Justin Jefferson, Rams defensive stalwart Aaron Donald and Patriots cornerback Christian Gonzalez. Teams finalized their practice reports late in the week, and below is a game-by-game summary of who’s expected to play, who’s out and who remains questionable.
Colts at Commanders (London)
– Keenan Allen was a full no-show in Friday practice after two limited sessions earlier in the week; if he’s unavailable, targets will likely shift to tight end Tyler Warren and wide receiver Josh Downs. Dulin practiced fully Friday despite being listed questionable and could factor in.
– The Commanders have ruled out QB Jayden Daniels despite the trip to London, so Marcus Mariota will start again. Terry McLaurin was limited on Friday with a hamstring issue and is questionable.
Patriots at Bills
– New England will be missing two defensive starters: CB Christian Gonzalez and DT Christian Barmore, both out with shoulder injuries and unable to practice all week. RT Morgan Moses returned to limited practice Friday and is listed as questionable with a foot injury.
– Buffalo could be without DL T.J. Sanders, who was limited late in the week after missing Wednesday and is considered doubtful due to illness. CB Christian Benford didn’t practice this week with a toe issue and is questionable.
Jets at Bears
– The Jets will be without RB Breece Hall (quad), so Braelon Allen is expected to start. WR Adonai Mitchell is out, and rookie TE Kenyon Sadiq is questionable with a back injury after working limited practices.
– Caleb Williams remains out as he continues hamstring recovery; the Bears haven’t confirmed his replacement, with Tyson Bagent and Case Keenum the primary candidates. RB D’Andre Swift returned as a full participant Friday after missing Thursday with a knee issue and is expected to play.
Jaguars at Bengals
– Jacksonville is largely healthy with no players ruled out; Regis, Brown and Braswell were limited during the week.
– Cincinnati got limited practice participation from B.J. Hill on Friday, giving him a chance to play. Bozeman, also questionable, did not practice Friday after being limited Thursday.
Cardinals at Giants
– Arizona has just one player out: Dadrion Taylor-Demerson (back), who missed practice all week. Edge rusher Josh Sweat was limited Friday with a groin concern.
– New York enters Week 4 without any listed injuries or game-day designations.
Rams at Eagles
– Aaron Donald will miss this game after being held out of practice all week with a back injury. Ferguson is out and has been placed on injured reserve. On offense, Puka Nacua (hip) returned to full participation and has no game designation.
– Philadelphia will be without WR DeVonta Smith, who missed practice with a hamstring injury. LB Zack Baun didn’t practice due to a concussion and is out for the matchup.
Packers at Buccaneers
– Packers out: G Aaron Banks (knee, toe), DT Warren Brinson (calf, groin), DT Anthony Campbell (ankle), IOL Jacob Monk (quad). Questionable: IOL Jager Burton (groin), LB Edgerrin Cooper (shoulder, concussion) — Cooper was a full participant Friday and could play.
– Buccaneers out: OLB Rueben Bain Jr. (groin, shoulder), TE Ko Kieft (elbow), QB Baker Mayfield (right thumb), CB Benjamin Morrison (quad). Questionable: LB SirVocea Dennis (calf), DL Rakeem Nunez-Roches (ankle/foot), CB Jacob Parrish (not injury related). With Mayfield out, undrafted rookie Jalon Daniels will start; rookie RB Bucky Irving returned to full practice Friday after being limited earlier in the week and is expected to play.
Titans at Ravens
– Tennessee listed just two players on the final report; Spears practiced fully while Winston Jr. did not practice Friday with a shoulder issue.
– Baltimore won’t have pass rusher Trey Hendrickson after a procedure for a broken finger. The Ravens limited Zay Flowers and held out Ronnie Stanley on Friday, listing both as questionable — those moves appear precautionary as the team manages their workloads ahead of the game.
Cowboys at Texans
– Dallas ruled out Durant and Overshown (both hamstring injuries) after neither practiced this week. Newly acquired CB Joey Porter Jr. carries no injury designation and looks ready to debut.
– The Texans ruled out LB Al-Shaair and S M.J. Stewart (who did not practice Friday after a full practice Thursday). WR Nico Collins (hamstring) practiced fully Friday and is expected to play.
Dolphins at Vikings
– Miami’s Week 3 loss included the season-ending ACL for RB De’Von Achane, who has been placed on IR. Douglas and Beal did not practice this week.
– The Vikings will be without WR Justin Jefferson (ankle), who missed practice all week and is ruled out. Jordan Addison should see increased targets in Jefferson’s absence.
Chiefs at Raiders
– Kansas City is mostly healthy with OT Josh Simmons the only player listed; coach Andy Reid said Simmons is dealing with a bulging disk.
– Las Vegas also has a clean bill aside from Powers-Johnson, who is out after missing practice this week with a groin injury.
Broncos at 49ers
– Denver’s only game-day designation is OLB Dondrea Tillman (hamstring), who didn’t practice this week.
– San Francisco has starting LT Trent Williams available with no designation, but Mike Evans and LB Dre Greenlaw are both questionable; coach Kyle Shanahan called Evans a game-time decision.
Chargers at Seahawks
– Chargers out: G Kayode Awosika (fibula), TE Charlie Kolar (forearm), WR Brenen Thompson (quad), DL Dalvin Tomlinson (hamstring). Questionable: CB Donte Jackson (concussion), S Derwin James Jr. (hamstring, rested), QB Trey Lance (groin), WR Ladd McConkey (foot), DB Elijah Molden (hamstring). McConkey returned to limited practice Friday, and James also practiced limited Friday, improving their chances.
– Seahawks out: RB Zach Charbonnet (knee), RB Jadarian Price (chest). Questionable: S Ty Okada (hamstring), LB Chazz Surratt (calf). With Price out, Emanuel Wilson and George Holani are expected to handle carries.
Lions at Panthers
– Detroit will be without Bartch (did not practice) and listed corner Reed as questionable after limited work this week.
– Carolina has Legette and Lewis ruled out, and corners Jaycee Horn and Mike Jackson were placed on IR. WR Jalen Coker is questionable with a quad injury after limited practices Thursday and Friday.
Falcons at Saints (Monday)
– Analysis to come.
Fan Take:
Injuries to marquee players like Justin Jefferson, Aaron Donald and Christian Gonzalez will shift game plans and open opportunities for lesser-known players to step up — which can change the playoff landscape rapidly early in the season. For fans, this underscores how quickly a team’s fortunes can swing and why depth and smart roster management are as important as star power in determining success.
Source: www.cbssports.com

