The NFL moves into October with Week 4 underway, featuring the first of three London games this season — extending Sunday’s schedule overseas — and a Monday Night divisional showdown. As usual, CBSSports.com and SportsLine have gathered expert spreads, best bets and deeper analysis in one spot, with wagering lines provided by DraftKings Sportsbook. SportsLine’s projection model, which runs 10,000 simulations per matchup, is also highlighted as a resource for bettors.
Indianapolis Colts at Washington Commanders (London)
– Time: Sunday, 9:30 a.m. ET (NFL Network). Open: Commanders -1.5, O/U 48.5.
– Pick: Pete Prisco favors the Colts in a late rally, projecting a 31-30 win after expecting both teams to put up points.
New England Patriots at Buffalo Bills
– Time: Sunday, 1 p.m. ET (CBS). Open: Bills -3, O/U 49.5.
– Take: SportsLine’s Josh Nagel doubts New England will look sharp after a heavy loss last week, and teases involving this game are available from his card.
New York Jets at Chicago Bears
– Time: Sunday, 1 p.m. ET (FOX). Open: Bears -8.5, O/U 45.5.
– Pick: Eric Cohen backs the Bears, applauding Chicago’s coaching and ground game after another standout performance from Case Keenum under Ben Johnson’s plan.
Jacksonville Jaguars at Cincinnati Bengals
– Time: Sunday, 1 p.m. ET (CBS). Open: Bengals -2.5, O/U 51.5.
– Pick: John Breech sides with Cincinnati in a close AFC matchup, noting Trevor Lawrence’s historical struggles versus the Bengals and Cincinnati’s ability to capitalize when opponents falter.
Arizona Cardinals at New York Giants
– Time: Sunday, 1 p.m. ET (CBS). Open: Giants -7, O/U 45.5.
– Pick: Pete Prisco predicts an upset, taking Arizona to win 24-21 at MetLife after the Cardinals showed promise against better competition.
Los Angeles Rams at Philadelphia Eagles
– Time: Sunday, 1 p.m. ET (FOX). Open: Rams -1.5, O/U 47.5.
– Pick: Jordan Dajani leans to the visiting Rams (26-20), citing concerns about Philadelphia’s inconsistent offense and lack of early scoring this year.
Green Bay Packers at Tampa Bay Buccaneers
– Time: Sunday, 1 p.m. ET (FOX). Open: Packers -1.5, O/U 47.5.
– Pick: Eric Cohen expects Green Bay to win and cover, despite recent poor play and questions around coaching, while Tampa Bay’s offense remains a mess and may turn to an inexperienced rookie QB.
Tennessee Titans at Baltimore Ravens
– Time: Sunday, 1 p.m. ET (CBS). Open: Ravens -8.5, O/U 47.5.
– Note: Baltimore is one of the week’s biggest favorites; SportsLine’s R.J. White discusses survivor-pool strategy and whether to take the chalk or pivot.
Dallas Cowboys at Houston Texans
– Time: Sunday, 1 p.m. ET (FOX). Open: Texans -2.5, O/U 47.5.
– Pick: Tyler Sullivan expects Dallas to win outright, pointing to Houston’s struggling offensive line and the Cowboys’ efficient scoring drives as keys.
Miami Dolphins at Minnesota Vikings
– Time: Sunday, 4:05 p.m. ET (FOX). Open: Vikings -7.5, O/U 43.5.
– Pick: Tyler Sullivan likes the Vikings to cover, noting Miami’s offensive decline after losing RB De’Von Achane and Minnesota’s aggressive blitz-heavy defense under Brian Flores.
Denver Broncos at San Francisco 49ers
– Time: Sunday, 4:25 p.m. ET (CBS). Open: 49ers -2.5, O/U 46.5.
– Pick: Jared Dubin expects the 49ers to remain unbeaten, praising San Francisco’s top-tier offense and Shanahan-Purdy combination.
Kansas City Chiefs at Las Vegas Raiders
– Time: Sunday, 4:25 p.m. ET (CBS). Open: Chiefs -5.5, O/U 43.5.
– Pick: Eric Cohen takes the Chiefs in a marquee AFC West clash, believing Kansas City’s offense gives them a clear edge.
Los Angeles Chargers at Seattle Seahawks
– Time: Sunday, 4:25 p.m. ET (CBS). Open: Seahawks -3, O/U 45.5.
– Pick: Tyler Sullivan backs the Seahawks to bounce back at home, expecting a dominant performance from their offense now that their veteran QB is back.
Detroit Lions at Carolina Panthers (Sunday Night)
– Time: Sunday, 8:20 p.m. ET (NBC). Open: Lions -3, O/U 47.5.
– Note: SportsLine’s Larry Hartstein — who has a strong recent record on Lions-related picks — is leaning Over; his full spread analysis is available on SportsLine.
Atlanta Falcons at New Orleans Saints (Monday Night)
– Time: Monday, 8:15 p.m. ET (ESPN). Open: Saints -2.5, O/U 45.5.
– Note: Larry Hartstein also weighs in on this matchup and is inclined toward the Over; his Falcons-related picks have been profitable of late.
Fan Take (two sentences):
Week 4 is where early-season storylines start to harden — coaches, quarterback play and injuries now shape which teams look like real contenders and which are likely to fall back. The London game and high-profile matchups this week matter not only for playoff positioning but for how fanbases and bettors recalibrate expectations for the rest of the season.
Source: www.cbssports.com
