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Reading: Master the 2025 49ers Betting Game: Super Bowl Odds, Points Totals, Prop Bets, and San Francisco’s Top Picks
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Sports Daily > NFL > Master the 2025 49ers Betting Game: Super Bowl Odds, Points Totals, Prop Bets, and San Francisco’s Top Picks
How to Bet on 49ers in 2025: Super Bowl Odds, Gain Totals, Props, San Francisco's Best Bet
NFL

Master the 2025 49ers Betting Game: Super Bowl Odds, Points Totals, Prop Bets, and San Francisco’s Top Picks

August 4, 2025 3 Min Read
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The 2024 season was a disaster for the San Francisco 49ers, with numerous injuries derailing their chances and resulting in a disappointing 6-11 record. Key losses included four running backs, one receiver, and multiple linemen on both offense and defense. Linebacker Dre Greenlaw, who had a rough time in the previous Super Bowl, only managed 34 snaps before reinjuring himself. Only 13 players appeared in all 17 games, and a mere six started each game, showcasing the team’s lack of consistency.

Heading into 2025, the 49ers face health challenges again, especially with receiver Brandon Aiyuk still recovering from ACL and MCL tears, possibly sidelining him for the entire season. The offseason strategy is focused heavily on bolstering the defense, which ranked 29th in scoring last year. Under new defensive coordinator Robert Saleh, the team signed edge rusher Bryce Huff and drafted defensive line talents Mykel Williams and Alfred Collins. They also added depth to the secondary with five free agents and two draft picks, plus three linebackers, aiming for a more resilient defense. A healthier lineup and a manageable schedule could help the 49ers reclaim their status as Super Bowl contenders.

Review of the 2024 season reveals a low finish in the NFC West and no playoff appearance, with Brock Purdy’s record dropping to 6-9 after a strong start in previous years. The 2025 roster sees returning and new players across positions but still faces concerns, particularly at quarterback and wide receiver. Betting odds suggest cautious optimism for 2025, with moderate chances to make the playoffs and win the NFC West or Super Bowl, reflecting uncertainty but potential.

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Among player props, Brock Purdy’s MVP odds remain long, while hopes for Christian McCaffrey’s rushing yards are high if he can stay healthy, underpinning the team’s offensive potential. The 49ers’ strengths lie in improved luck with injuries, a less taxing schedule, and strategic additions to both offense and defense. Yet, they face challenges in recovering from key injuries and integrating new defensive players in a tough NFC West division with strong rivals like the Seahawks and Rams.

In summary, betting on the 49ers in 2025 may be wise with their projected improvement, especially with standout players like McCaffrey and Purdy poised to perform. However, the team must overcome significant injury risks and quick adaptation of new personnel. Success will depend on health, defense cohesion, and stepping up in critical games within a competitive NFC West.

Fan Take: This update is crucial for NFL fans as it highlights the unpredictable nature of football seasons, where injuries can drastically change a team’s fortunes. For the 49ers, 2025 could mark a pivotal comeback, showing how resilience and smart roster moves might redefine their quest for another Super Bowl run.

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