All 32 NFL teams are grappling with injuries as Week 4 begins. Carolina lost its top two cornerbacks to injured reserve, Tampa Bay will be without QB Baker Mayfield for several weeks after a dislocated thumb, and Miami’s explosive running back De’Von Achane is out for the year with a torn ACL. On the brighter side, San Francisco’s Mike Evans is not expected to miss much time with a rib strain, and Houston’s Nico Collins is back at practice after sitting out two games with a hamstring issue — a welcome development for C.J. Stroud as the Texans try to climb out of an 0-3 hole.
(Odds: DraftKings Sportsbook)
Pittsburgh Steelers (-2.5) at Cleveland Browns
– Steelers: Joey Porter Jr. won’t play Thursday despite being a full practice participant Monday and Tuesday and limited Wednesday; he has yet to appear in a game this season. RB Rico Dowdle is out after missing practice all week with a toe problem.
– Browns: Deshaun Watson will be without starters Elgton Jenkins (concussion) and Teven Jenkins (back), both ruled out after limited practices earlier in the week.
Indianapolis Colts (-3.5) vs. Washington Commanders (London)
– Colts: TE Mo Alie-Cox (illness) and WR Ashton Dulin (ankle) missed Wednesday practice; LB Akeem Davis-Gaither (knee) was the only limited player with an injury designation.
– Commanders: Several did not practice Wednesday, including OG Sam Cosmi (concussion/throat), S Nick Cross (illness) and RB Rachaad White (shoulder). A long list of players were limited, among them QB Jayden Daniels (elbow), DL Javon Kinlaw (shoulder) and TE Chig Okonkwo (hamstring).
Tennessee Titans at Baltimore Ravens (-11.5)
– Titans: DL John Franklin-Myers (back), RB Tony Pollard (foot) and RB Tyjae Spears (ankle) did not practice Wednesday.
– Ravens: Trey Hendrickson (finger) missed practice, as did centers Jovaughn Gwyn (ankle) and Ethan Pocic (knee). Multiple starters were limited, including WR Zay Flowers (hamstring), CB Marlon Humphrey (hamstring) and OT Ronnie Stanley (toe). QB Lamar Jackson was limited for back tightness but says he plans to play Sunday.
New England Patriots at Buffalo Bills (-6.5)
– Patriots: DT Christian Barmore (shoulder), CB Christian Gonzalez (shoulder) and OT Morgan Moses (foot) missed Wednesday. Several players were limited, including LB Christian Elliss (chest) and DE Dre’Mont Jones (shoulder). QB Drake Maye was listed with a right shoulder issue but practiced fully.
– Bills: LB Joe Anderson (knee), CB Christian Benford (toe), WR Keon Coleman (ankle) and DL T.J. Sanders (illness) did not practice. S Damar Hamlin (ribs) and WR DJ Moore (shoulder) were limited.
Dallas Cowboys at Houston Texans (-2.5)
– Texans: LB Azeez Al-Shaair (groin), RB British Brooks (hamstring) and OT Trent Brown (illness/knee/wrist) missed practice. LBs Will Anderson Jr. (ankle) and Jadeveon Clowney (knee), WR Nico Collins (hamstring) and others were limited.
– Cowboys: CB Shavon Revel Jr. (knee/ankle), LB DeMarvion Overshown (hamstring) and CB Cobie Durant (hamstring) missed practice; S Malik Hooker was limited with a forearm issue.
Jacksonville Jaguars at Cincinnati Bengals (-2.5)
– Jaguars: A number of players were limited in Wednesday practice, including RB LeQuint Allen Jr. (hip), CBs Christian Braswell (knee) and Montaric Brown (hamstring), and WR Jakobi Meyers (thumb).
– Bengals: DT B.J. Hill (Achilles), S Kyle Dugger (quad), OG Dalton Risner (knee) and WR Colbie Young (knee) did not practice. Safeties Jordan Battle (hamstring) and Bryan Cook (ankle) were limited.
Los Angeles Rams (-3) at Philadelphia Eagles
– Rams: DT Aaron Donald (back), CB Jaylen Watson (shoulder) and TEs Terrance Ferguson (ankle) and Colby Parkinson (knee/shoulder) missed Wednesday practice. Puka Nacua (hip) and others were limited.
– Eagles: WR DeVonta Smith (hamstring), RB Will Shipley (foot), OT Fred Johnson (knee), TE Dallas Goedert (knee), WR Marquise Brown (ankle) and LB Zack Baun (concussion) did not practice; a few defenders were limited.
New York Jets at Chicago Bears (-3.5)
– Jets: RB Breece Hall (quad), LB Kiko Mauigoa (quad), WR Adonai Mitchell (finger), OG Dylan Parham (knee) and TE Mason Taylor (thumb) missed practice. Several others, including S Minkah Fitzpatrick (groin), were limited.
– Bears: OT Braxton Jones (knee), QB Caleb Williams (hamstring) and OL Jonah Jackson (personal) missed Wednesday, while DB Cam Lewis (hip) and LB Noah Sewell (Achilles) were limited.
Green Bay Packers (-3.5) at Tampa Bay Buccaneers
– Buccaneers: A tough week — rookie edge Rueben Bain Jr. (groin/shoulder), Yaya Diaby (calf/shoulder), WR Chris Godwin Jr. (ankle), TE Ko Kieft (elbow), QB Baker Mayfield (right thumb), DL Rakeem Nunez-Roches (ankle/foot) and others missed practice. Several players were limited, including LB SirVocea Dennis (calf) and RB Bucky Irving (glute).
– Packers: OG Aaron Banks (knee/toe), DT Karl Brooks (illness), DT Anthony Campbell (ankle) and OG Jacob Monk (quadriceps) missed practice. DT Warren Brinson (calf/groin), LB Edgerrin Cooper (shoulder/concussion) and LB Lukas Van Ness (shoulder) were limited.
Arizona Cardinals (-2.5) at New York Giants
– Giants: OT Andrew Thomas (groin) and RB Tyrone Tracy Jr. (knee) missed practice; CB Deonte Banks and S Tyler Nubin were limited with calf issues.
– Cardinals: S Dadrion Taylor-Demerson (back) was the lone player who didn’t practice Wednesday. Several linemen and LBs, including Hjalte Froholdt (knee) and Mack Wilson (thumb), were limited.
Miami Dolphins at Minnesota Vikings (-10.5)
– Dolphins: EDGE Robert Beal Jr. (hamstring) and WR Caleb Douglas (ankle) missed practice. WR Chris Bell (knee), CB Storm Duck (knee) and RB Jaylen Wright (stinger/foot) were limited.
– Vikings: WR Justin Jefferson (ankle), punter Brett Thorson (right hamstring) and CB Charles Demmings (hamstring) did not practice; LB Blake Cashman was limited (elbow).
Kansas City Chiefs (-4.5) at Las Vegas Raiders
– Chiefs: OT Josh Simmons missed Wednesday with a back issue; CB L’Jarius Sneed was limited with a knee concern. Patrick Mahomes (knee) and DT Chris Jones (calf) were listed but were full participants.
– Raiders: OL Jackson Powers-Johnson missed practice with a groin issue. RB Ashton Jeanty was on the report for an ankle but practiced fully.
Los Angeles Chargers at Seattle Seahawks (-7)
– Chargers: OG Kayode Awosika (fibula), DL Justin Eboigbe (eye), CB Donte Jackson (concussion), TE Charlie Kolar (forearm), WR Brenen Thompson (quadriceps) and DL Dalvin Tomlinson (hamstring) missed practice. S Derwin James (hamstring) and others were limited.
– Seahawks: Ty Okada was the lone absence (hamstring). Several players were limited, including OL Grey Zabel (groin), DT Jarran Reed (foot) and S Julian Love (calf).
Denver Broncos at San Francisco 49ers (-3)
– Broncos: EDGE Dondrea Tillman (hamstring) sat out practice. WR Jaylen Waddle (foot), Marvin Mims Jr. (foot) and RB J.K. Dobbins (hip) were full participants.
– 49ers: WR Mike Evans (ribs), LB Dre Greenlaw (quad), WR KhaDarel Hodge (knee), DT James Thompson Jr. (ankle) and DE Keion White (hamstring) did not practice. DEs Romello Height (hand) and Mykel Williams (knee) were limited. OT Trent Williams appeared on the report with a neck issue but was also marked as a resting player.
Detroit Lions (-3.5) at Carolina Panthers (SNF)
– Lions: OL Ben Bartch (foot) and EDGE D.J. Wonnum (back) missed practice; CB D.J. Reed was limited with a rib issue.
– Panthers: The injury picture is dire — starters Jaycee Horn and Mike Jackson were placed on injured reserve. Wednesday practice saw WRs Jalen Coker (quad) and Xavier Legette (knee), OG Damien Lewis (elbow), EDGE Princely Umanmielen (ankle) and OT Monroe Freeling (concussion) absent. Positive notes: LB Devin Lloyd (calf) and QB Bryce Young (knee) fully participated.
Fan Take:
Week 4’s injury sheet underscores how quickly rosters can be reshaped and why depth matters — losses to key starters like Mayfield and Achane can swing short-term expectations and open opportunities for backups. For fans, this is a reminder that football is as much about roster resilience and coaching adjustments as it is about star power, and the next few weeks could produce surprising breakout performances and shake up playoff projections.
Source: www.cbssports.com
