The Week 4 NFL odds board is the last full slate for a bit, with all 16 games intact before byes begin in Week 5. The league’s first London game of the season pits the Colts against the Commanders, with Indianapolis installed as a 4.5-point favorite and Jayden Daniels (elbow) officially out. Sunday features only two divisional matchups — Patriots at Bills (Buffalo -7) and Chiefs at Raiders (Kansas City +4.5) — while Monday night’s game is a division rivalry between the Saints and Falcons (New Orleans -2), played on the 20th anniversary of the Saints’ 2006 “Domecoming.” Claim the latest Polymarket promo code CBSSPORTS to get a $25 bonus after $10 in trades.
If you’re hunting for heavy favorites in Week 4, the Ravens are overwhelming 11.5-point chalk over a winless Titans team, and the Vikings are 10-point favorites against an 0-3 Dolphins squad — even with Justin Jefferson (ankle) sidelined. All of the updated Week 4 lines are available below, and SportsLine’s advanced computer model — which runs each matchup 10,000 times — has issued betting advice and matchup predictions for every game.
According to SportsLine, the model has produced strong long-term returns, reportedly netting more than $7,000 for $100 bettors on its top-rated NFL selections since it began, and it enters Week 4 riding a 54-43 run on top picks dating back to 2024. It’s now released locked-in choices for each Week 4 matchup; see every pick at SportsLine. New users interested in markets and trading can also check our Kalshi promo code review — use CBSSPORTS55 to get a $55 bonus after $25+ in trades.
Top Week 4 calls from the model include:
– Giants (+2.5, total 44.5) to cover against the Cardinals (Sunday, 1 p.m. ET). The model argues Arizona’s early-season win looks less impressive with the Cards surrendering 31+ points in consecutive losses, and Arizona is just 5-9 ATS after a loss since last year. New York’s offense tops the league in time of possession and the defense benefits from strong starting field position; the model projects New York to cover in over half of simulations and gives the Over a roughly 56% chance.
– Seahawks (-7, total 42.5) to cover versus the Chargers. Despite L.A. forcing five turnovers in its loss to Buffalo, the Chargers have dropped six straight games (scoring 17 or fewer in each), while Seattle returns home after a long trip and a streak-ending road loss. Over the model’s simulations, Seattle covers in nearly 60% of outcomes and the Over clears 60% as well.
The model also lists winners and covers for all Week 4 matchups and identifies five teams it expects to win by double digits — useful targets if you’re considering alternate lines. For full picks and detailed projections, visit SportsLine.
Fan Take: Week 4’s full slate — capped by several lopsided favorites and a marquee London matchup — gives fans an early read on which contenders are separating themselves and which franchises are in trouble. The favorite-driven lines and model-driven picks matter because they influence betting markets and public perception, which can sway narratives and team decision-making as the season’s first quarter wraps up.
Source: www.cbssports.com
